Clotting factor XIII and desmopressin improve hemostasis in uncontrolled bleeding.

PURPOSE: To investigate hemostatic effects of supplementary factor XIII and desmopressin (DDAVP) in resuscitation of uncontrolled bleeding. METHODS: Fifty-four rabbits were randomized in nine groups: G1: Sham; G2: FXIII and normotensive resuscitation (NBP); G3: FXIII and permissive hypotension (PH) (MAP 60% baseline); G4: FXIII/DDAVP/NBP; G5: FXIII/DDAVP/PH; G6: NBP only; G7: FXIII no hemorrhage; G8: FXIII/DDAVP no hemorrhage; G9: PH only. Thromboelastometry and intra-abdominal blood loss were assessed. Scanning electron microscopy (EM) of the clots was performed. RESULTS: Compared to Sham, only G8 (FXIII/DDAVP w/o hemorrhage) showed clotting time (CT) significantly lower (p<0.05). NBP alone (G6) resulted in significantly prolonged CT compared to G2, G3 and G5 (p<0.05). Similarly, median alpha angle was significantly larger in G3,4,5, and 9 compared to G6 (p<0.05). Area under the curve was significantly greater in G5 than G2. Intra-abdominal blood loss was lower in G5 and G9 compared to G2 and G6. FXIII/DDAVP and PH resulted in more robust fibrin mesh by EM. CONCLUSIONS: Normotensive resuscitation provokes more bleeding and worsens coagulation compared to pH, that is partially reversed by factor XIII and desmopressin. FXIII and DDAVP can synergistically improve coagulation. Permissive hypotension reduces bleeding regardless of those agents.

Clotting Factor XIII and desmopressin improve hemostasis in uncontrolled bleeding

PURPOSE: To investigate hemostatic effects of supplementary factor XIII and desmopressin (DDAVP) in resuscitation of uncontrolled bleeding. METHODS: Fifty-four rabbits were randomized in nine groups: G1: Sham; G2: FXIII and normotensive resuscitation (NBP); G3: FXIII and permissive hypotension (PH) (MAP 60% baseline); G4: FXIII/DDAVP/NBP; G5: FXIII/DDAVP/PH; G6: NBP only; G7: FXIII no hemorrhage; G8: FXIII/DDAVP no hemorrhage; G9: PH only. Thromboelastometry and intra-abdominal blood loss were assessed. Scanning electron microscopy (EM) of the clots was performed. RESULTS: Compared to Sham, only G8 (FXIII/DDAVP w/o hemorrhage) showed clotting time (CT) significantly lower (p<0.05). NBP alone (G6) resulted in significantly prolonged CT compared to G2, G3 and G5 (p<0.05). Similarly, median alpha angle was significantly larger in G3,4,5, and 9 compared to G6 (p<0.05). Area under the curve was significantly greater in G5 than G2. Intra-abdominal blood loss was lower in G5 and G9 compared to G2 and G6. FXIII/DDAVP and PH resulted in more robust fibrin mesh by EM. CONCLUSIONS: Normotensive resuscitation provokes more bleeding and worsens coagulation compared to pH, that is partially reversed by factor XIII and desmopressin. FXIII and DDAVP can synergistically improve coagulation. Permissive hypotension reduces bleeding regardless of those agents. .

Hipotensão permissiva no trauma / Permissive hypotension in trauma

O choque hemorrágico é uma das principais causas de mortes evitáveis no trauma.Os protocolos atuais de tratamento reconhecem a importância da abordagem precoce da coagulopatia relacionada ao trauma e que a infusão de grandes volumes de cristaloides são prejudiciais aos pacientes. O controle rápido do sangramento continua sendo a medida mais importante no tratamento do choque hemorrágico. Neste contexto, a hipotensão permissiva é uma estratégia cada vez mais utilizada na reanimação de pacientes com hemorragias traumáticas. Neste artigo realizamos uma revisão da literatura com uma análise crítica das indicações da hipotensão permissiva no trauma.

Hemorrhagic shock is one of the leading causes of preventable deaths in trauma cases. Current treatment protocols acknowledge the importance of the early approach of coagulopathy related to trauma and that the infusion of large volumes of crystalloids is harmful to patients. The quick bleeding control is still the most important measure in the treatment of hemorrhagic shock. Thus, the permissive hypotension is a strategy increasingly being used in the resuscitation of patients with traumatic bleeding. In this article, we conducted a literature review with a critical analysis of indications for permissive hypotension in trauma.

Implementation of a trauma registry in a Brazilian public hospital: the first 1,000 patients.

OBJECTIVE: Show the steps of a Trauma Registry (TR) implementation in a Brazilian public hospital and evaluate the initial data from the database. METHODS: Descriptive study of the a TR implementation in João XXIII Hospital (Hospital Foundation of the state of Minas Gerais) and analysis of the initial results of the first 1,000 patients. RESULTS: The project was initiated in 2011 and from January 2013 we began collecting data for the TR. In January 2014 the registration of the first 1000 patients was completed. The greatest difficulties in the TR implementation were obtaining funds to finance the project and the lack of information within the medical records. The variables with the lowest completion percentage on the physiological conditions were: pulse, blood pressure, respiratory rate and Glasgow coma scale. Consequently, the Revised Trauma Score (RTS) could be calculated in only 31% of cases and the TRISS methodology applied to 30.3% of patients. The main epidemiological characteristics showed a predominance of young male victims (84.7%) and the importance of aggression as a cause of injuries in our environment (47.5%), surpassing traffic accidents. The average length of stay was 6 days, and mortality 13.7%. CONCLUSION: Trauma registries are invaluable tools in improving the care of trauma victims. It is necessary to improve the quality of data recorded in medical records. The involvement of public authorities is critical for the successful implementation and maintenance of trauma registries in Brazilian hospitals.

Implementation of a trauma registry in a brazilian public hospital: the first 1,000 patients / Implantação de um registro de trauma em um hospital público brasileiro: os primeiros 1000 pacientes

OBJECTIVE: Show the steps of a Trauma Registry (TR) implementation in a Brazilian public hospital and evaluate the initial data from the database. METHODS: Descriptive study of the a TR implementation in João XXIII Hospital (Hospital Foundation of the state of Minas Gerais) and analysis of the initial results of the first 1,000 patients. RESULTS: The project was initiated in 2011 and from January 2013 we began collecting data for the TR. In January 2014 the registration of the first 1000 patients was completed. The greatest difficulties in the TR implementation were obtaining funds to finance the project and the lack of information within the medical records. The variables with the lowest completion percentage on the physiological conditions were: pulse, blood pressure, respiratory rate and Glasgow coma scale. Consequently, the Revised Trauma Score (RTS) could be calculated in only 31% of cases and the TRISS methodology applied to 30.3% of patients. The main epidemiological characteristics showed a predominance of young male victims (84.7%) and the importance of aggression as a cause of injuries in our environment (47.5%), surpassing traffic accidents. The average length of stay was 6 days, and mortality 13.7%. CONCLUSION: Trauma registries are invaluable tools in improving the care of trauma victims. It is necessary to improve the quality of data recorded in medical records. The involvement of public authorities is critical for the successful implementation and maintenance of trauma registries in Brazilian hospitals. .

OBJETIVO: apresentar as etapas da implantação de um Registro de Trauma (RT) em hospital público brasileiro e avaliar os dados iniciais deste banco de dados. MÉTODOS: estudo descritivo da implantação de um RT no Hospital João XXIII - FHEMIG (Fundação Hospitalar do Estado de Minas Gerais) e análise dos resultados iniciais dos primeiros 1000 pacientes. RESULTADOS: o projeto foi iniciado em 2011 e, a partir de janeiro de 2013, iniciamos a coleta de dados para o RT e em janeiro de 2014 completamos o registro dos primeiros 1000 pacientes. As maiores dificuldades na implantação do RT foram obter recursos para o financiamento do projeto e a falta de informações nos prontuários médicos. As variáveis com os menores percentuais de preenchimento foram sobre as condições fisiológicas: pulso, pressão arterial, frequência respiratória e escala de coma de Glasgow. O Revised Trauma Score (RTS) foi calculado em 31% dos casos e a metodologia TRISS aplicada em 30,3% dos pacientes. As principais características epidemiológicas mostraram um predomínio de vítimas jovens do sexo masculino (84,7%) e a importância das agressões como causa de lesões (47,5%), superando os acidentes de trânsito. O tempo médio de permanência foi seis dias e a mortalidade, 13,7%. CONCLUSÃO: os registros de trauma são ferramentas de grande valor para melhorar a assistência às vítimas de trauma. É necessário melhorar a qualidade do registro de dados no prontuário médico. O envolvimento do poder público é fundamental para a implantação e manutenção dos RT nos hospitais brasileiros. .

[Epidemiology of powdered glass-coated kite line injuries: victims admitted to a trauma hospital in Belo Horizonte, Brazil]. / Epidemiologia dos acidentes provocados por linhas com cerol: estudo de vítimas atendidas em hospital de trauma em Belo Horizonte, Brasil.

OBJECTIVE: To describe the characteristics of victims of powdered glass-coated (manja) kite line injuries admitted to a trauma hospital in Belo Horizonte, Brazil. METHODS: Cross-sectional study of victims with powdered glass-coated kite line injuries between 2005 and 2009. Data were obtained retrospectively from medical records. Central tendency and comparison of ratios were used to characterize victims. RESULTS: 211 victims were admitted between 2005 and 2009, 94% of which males. The majority of cases occurred in June and July (37% e 41.7%, respectively). Mean age was 15 years, with no difference between men and women. For the group of victims as a whole, upper limbs were the most prevalent site of injury, although neck and face injuries were the main site of injury among motorcyclists and cyclists. Two deaths (0.95%) were identified, both in motorcyclists, due to injury to neck structures. Residences were concentrated in three administrative areas (East, Northeast and South-central). CONCLUSION: Although the majority of injuries recorded were not severe, fatal injuries can occur, mainly among motorcyclists. Educational and preventive measures are needed to avoid potentially fatal injuries.

Epidemiologia dos acidentes provocados por linhas com cerol: estudo de vítimas atendidas em hospital de trauma em Belo Horizonte, Brasil / Epidemiology of powdered glass-coated kite line injuries: victims admitted to a trauma hospital in Belo Horizonte, Brazil

OBJETIVO: Descrever as características das vítimas de acidentes por linhas com cerol atendidas em hospital de trauma de Belo Horizonte, Brasil. MÉTODOS: Estudo seccional com vítimas de acidentes por linhas com cerol no período de 2005 a 2009. Os dados foram coletados retrospectivamente nos prontuários médicos. Foram utilizadas medidas de tendência central e comparação entre proporções para descrever as características das vítimas. RESULTADOS: Foram identificadas 211 vítimas no período estudado, 94% das quais eram do sexo masculino. Houve concentração do atendimento nos meses de junho e julho (37% e 41,7%, respectivamente). A média de idade foi de 15 anos, não havendo diferença entre os sexos. No conjunto das vítimas, os membros superiores foram o local mais prevalente de lesões, mas entre os motociclistas e ciclistas os principais locais de lesão foram o pescoço e a face. Foram registrados 2 óbitos (0,95%), ambos em motociclistas e causados por lesões das estruturas anatômicas do pescoço. O local de residência das vítimas se concentrou em distritos sanitários de Belo Horizonte (Leste, Nordeste e Centro-Sul). CONCLUSÃO: Apesar da benignidade das lesões identificadas no período estudado, podem ocorrer lesões fatais, principalmente em motociclistas. Medidas educativas e preventivas são necessárias para evitar a ocorrência de lesões potencialmente fatais.

OBJECTIVE: To describe the characteristics of victims of powdered glass-coated (manja) kite line injuries admitted to a trauma hospital in Belo Horizonte, Brazil. METHODS: Cross-sectional study of victims with powdered glass-coated kite line injuries between 2005 and 2009. Data were obtained retrospectively from medical records. Central tendency and comparison of ratios were used to characterize victims. RESULTS: 211 victims were admitted between 2005 and 2009, 94% of which males. The majority of cases occurred in June and July (37% e 41.7%, respectively). Mean age was 15 years, with no difference between men and women. For the group of victims as a whole, upper limbs were the most prevalent site of injury, although neck and face injuries were the main site of injury among motorcyclists and cyclists. Two deaths (0.95%) were identified, both in motorcyclists, due to injury to neck structures. Residences were concentrated in three administrative areas (East, Northeast and South-central). CONCLUSION: Although the majority of injuries recorded were not severe, fatal injuries can occur, mainly among motorcyclists. Educational and preventive measures are needed to avoid potentially fatal injuries.

A experiência assistencial da Fhemig na atenção a doenças infecciosas respiratórias agudas durante o enfrentamento da epidemia de Influenza A H1N1, no estado de Minas Gerais em 2009 / Fhemig experience in the care of acute respiratory infectious diseases during the fight against the H1N1 Influenza epidemic in Minas Gerais State in 2009

A epidemia pelo vírus influenza A H1N1 no estado de Minas Gerais mobilizou a sociedade e a resposta articulada dos serviços de saúde em ações coordenadas pelo Comitê Estadual. Objetivo: descrever o atendimento ambulatorial e hospitalar para doenças respiratórias infecciosas agudas realizado nas Unidades da rede Fhemig nas semanas epidemiológicas 33 a 41 de 2009. Método: estudo prospectivo de dados fornecidos semanalmente pelas unidades assistenciais à administração central, para fins de monitoramento e gestão da clínica. Resultados: ocorreu um total de 1.396 atendimentos no período em 11 unidades na região metropolitana de Belo Horizonte e interior do estado, com 29 por cento de internações em enfermarias e 6,7 em CTI, predomínio de pacientes de 15-24 anos, 42,4 por cento sem fatores de risco para complicações e 2,4 por cento de óbitos; 50 por cento (698) dos casos receberam antiviral oseltamivir. O pico de atendimentos ocorreu na 35ª semana (entre 30/08 e 05/09/2009). Confirmou-se influenza A H1N1 em 2,4 por cento dos casos atendidos e 399 exames permaneciam pendentes. Insuficiência renal dialítica, uso de ventilação mecânica e vasopressores foram preditores de óbito. Pneumonia associada à ventilação elevou o risco de óbito em 76 por cento (RR:1,76; IC 95 por cento 1,07-2,88). Conclusão: a Fhemig participou de forma articulada no processo assistencial durante a epidemia e desenvolveu mecanismos de gestão da clínica de forma a garantir a qualidade assistencial e responder à demanda da sociedade, junto com os demais parceiros.

Toracotomia de reanimação / Resuscitative thoracotomy

A toracotomia de reanimação é procedimento cirúrgico de emergência que pode salvar muitas vidas, desde que indicado no momento correto e em situações específicas. O objetivo deste artigo é rever os principais estudos publicados e, baseados numa análise crítica dos resultados apresentados, definir as melhores indicações desse procedimento.

The resuscitative thoracotomy is an emergency surgical procedure that may save many lives, since it is indicated on the right time and in specific situations. The objective of this article is to review the main studies published and based in a critical analysis of the presented result, define the best indications of this procedure

Registro de trauma: uma necessidade nos prontos-socorros do Brasil / Trauma registry: a necessity for Brazilian trauma centers

O trauma constitui-se em importante problema de saúde pública no Brasil, figurando entre as três primeiras causas de morte. O registro de trauma fornece informações úteis capazes de melhorar o atendimento às vítimas, definir medidas de prevenção, fornecer informações para aplicação de recursos e possibilitar fonte de dados para pesquisas científicas. O processo de implementação dos registros de trauma em hospitais não é dispendioso. Utiliza softwares específicos para obtenção de informações preestabelecidas das vítimas. A implementação desses registros nos prontos-socorros é também essencial para a integração de banco de dados de trauma em níveis estaduais e nacional.

Trauma is an important problem in the Brazilian public health system, appearing among the three first causes of death. The trauma registry provides useful information able to improve the victim's assistance, to define preventative measures, provide information for resources application and make possible a data source for scientific researches. The implementation process of trauma registry in hospitals isn't expensive. It uses specific softwares for getting the victims' pre-settled information. These registries implementation in the emergency rooms is also essential for the integration of trauma data banks at national and state levels

Fechamento precoce das colostomias em pacientes com trauma do reto: um estudo prospectivo e casualizado / Early colostomy closure in patients with rectal trauma: a prospective randomized trial

Foi feito um estudo prospectivo e casualizado de 35 pacientes portadores de colostomias devido a lesões traumáticas do reto admitidos no Hospital Jõao XXIIII no período de novembro de 1994 a junho de 1997. O objetivo foi avaliar os resultados do fechamento precoce das colostomias nestes pacientes. Após o atendimento inicial, os pacientes foram sorteados de acordo com o número do registro de admissão em dois grupos: os do grupo 1 (N = 14) foram submetidos ao fechamento precoce da colostomia programado para o 10o dia pós-operatório do tratamento da(s) lesão(ões) e os do grupo 2 (N = 21) submetidos ao fechamento tardio da colostomia, programado para oito semanas após a operação inicial. Nos dois grupos, o restabelecimentodo trânsito intestinal somente foi realizado após o fechamento da lesão retal confirmado por um estudoradiológico contrastado. Houve um predomínio de pacientes jovens, do sexo masculino e vítimas de traumatismopenetrante. Todos eram portadores de uma colostomia em alça. A taxa global de complicações após o fechamento das colostomias foi de 25,7%, com a infecção de ferida operatória sendo a complicação mais freqüente (17,1%). No grupo 1, as complicações ocorreram em 35,7% dos casos e, no grupo 2, em 19,1% (p = 0,423). A análise dos resultados permitiu-nos concluir que a taxa de complicações, a duração da operação para o fechamento da colostomia e o tempo total de permanência hospitalar não apresentaram diferenças significantes entre os dois grupos. Os pacientes submetidos ao fechamento precoce (grupo 1) permaneceram apenas 10 dias em média com a colostomia, enquanto nos pacientes do grupo 2 a média de permanência com a colostomia foi de 66,3 dias (p< 0,001 - Teste de Kruskal-Wallis). Baseados nestes resultados, concluímos que os pacientes portadores de...

A prospective and randomized trial involving 35 rectal trauma patients who were colostomized, as part of their surgical treatment, was undertaken at the João XXIII Hospital, between November 1994 and June 1997. The aim of this study was to evaluate the early results colostomy closure in this patient population. Rectal trauma victims were assigned for two groups, according to their hospital number. Group 1: Early colostomy closure, on the 10th post-operative day, and Group 2, delayed closure, eight weeks after theinitial operation. A contrast study of the rectum was performed in all patients prior to colostomy closure, in order to confirm the rectal healing. The majority were young male victims of penetrating trauma. All patients were submitted to a loop colostomy prior to the colostomy closure. The global complication rateafter colostomy closure was 25.7%. Postoperative wound infection was the most commom complication (17.11%). Complications occurred in 35.7% of the cases in group 1 and 19.1% in group 2(p = 0,423 ). We concluded that there was no significant difference between groups regarding complication rate, operative time for colostomy closure, and total hospital stay. Patients undergoing early closure (Group 1) stayed with a colostomy for an average of 10 days, while patients from delayed closure (Group 2) had their colostomy for an average of 66.3 days (p<0.001 - Kruskal-Wallis Test). Based on our findings, traumatic rectal injury victms who have a colostomy as part of their surgical treatment, may undergo earlycolostomy closure on the 10th post-operative day, as long as no complication of the initial operation ispresent.